RIKEN Immune Regenerative Medicine Inc. is a venture company spun off from RIKEN, the Japan's largest comprehensive Science Research Institute.

NKTWhat are NKT cells

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  • What are NKT cells

FIRSTLY

What are NKT cells(natural killer T cells)?

What are NKT cells (natural killer T cells)?
It is the fourth type of lymphocyte after T cells, B cells, and NK cells. The name NKT comes from the fact that it has the characteristics of both NK cells and T cells. NKT cells have a strong immune response enhancement effect, and by directly killing cancer cells and activating the immune system through IFN-γ production, they exert antitumor effects indirectly.We are developing an immuno-cell therapy that targets NKT cells.

  • 1986

    NKT cells are discovered

  • 1997

    Discovery of NKT cell ligand glycolipid (immune function active substance)

  • 2000

    Discovery of adjuvant action by NKT cells

Advantages of NKT cell-targeted therapy

  1. By simultaneously activating the innate and adaptive immune systems, it simultaneously attacks 2 types of “cancer cells” that are always present: (1) cancer cells with MHC and (2) cancer cells without MHC.
  2. Therefore, all patients and all cancers can be treated.
  3. Recovery from cancer-induced immunodeficiency.
  4. Fewer side effects because it activates the immune cells already present in the body
Advantages of NKT cell-targeted therapy | イメージ画像

SCONDLY

What is NKT cell-targeted therapy(natural killer T cell-targeted therapy)?

It has been shown to be highly effective in preventing recurrence.
It is the fourth type of lymphocyte after T cells, B cells, and NK cells. The name NKT comes from the fact that it has the characteristics of both NK cells and T cells.NKT cells have a strong immune response enhancement effect, and by directly killing cancer cells and IFN-γ production, they activate the immune system and exert an indirect antitumor effect.We are developing an immuno-cell therapy that targets NKT cells.

NKT細胞とは | イメージ画像

  • It is a treatment method in which blood is collected and cultured and dendritic cells are bound
    with an immunologically active substance and returned to the body.

    Doing so activates NKT cells in the body and exerts an antitumor effect.

THIRDLY

NKT cell-targeted treatment procedure

STEP
Outpatient at an affiliated medical institution (We will introduce affiliated medical institutions)
Component blood collection (apheresis) about 3 hours First visit, blood test (1 week)
NKT cell-targeted treatment procedure | STEP1
STEP
Cell culture room
The addition of a differentiation-inducing factor differentiates monocytes into dendritic cells.
成分採血 | STEP2

成分採血した単球（白血球の1つ）を細胞培養施設に移送します。

STEP
Cell creation (2 weeks including sterility inspection)
An immunologically active substance is added to the dendritic cells, which will continue to be cultured. The number of cells and the like will be checked.
NKT細胞標的治療手順 | STEP1
STEP
Outpatient at an affiliated medical institution
Dendritic cells are returned to the body by intravenous injection (drip administration). In NKT cell-targeted therapy, dendritic cells are returned to the body 4 times in total, once every 2 weeks.
NKT細胞標的治療手順 | STEP1

Dendritic cells bound with substances possessing specific functions are used as in-hospital preparations.